丛志奇
研究员
博士生导师
单碳酶催化研究组负责人
简历
2016年至今 中国科学院青岛生物能源与过程研究所 单碳酶催化研究组负责人
2013年-2016年 日本名古屋大学 研究员
2009年-2013年 日本分子科学研究所 博士研究员
2006年-2009年 日本熊本大学 获理学博士学位
学术经历
丛志奇研究员先后在日本分子科学研究所和名古屋大学从事金属酶及其相关领域的研究工作。在氯过氧化物酶、髓过氧化物酶、及细胞色素P450单加氧酶的分子机理与人工催化应用体系开发方面做出国际水平的成果。在包括JACS, Angew Chem,ACS Catal等国际权威学术杂志发表论文二十余篇，相关成果被ChemistryViews等科学媒体作为亮点报道。担任多个国际期刊审稿人(Tetrahedron/Tetrahedron Lett,2012, TOP10最佳审稿人奖)。2015年任第17次国际生物无机化学会议"金属蛋白和金属酶"分会主席。
获奖和荣誉
2018年 入选青岛市创新领军人才
代表性文章
2016年至今
13. Zhao, P.#; Kong, F.#; Jiang, Y.#; Qin, X.; Tian, X.; Cong, Z.* Enabling Peroxygenase Activity in Cytochrome P450 Monooxygenases by Engineering Hydrogen Peroxide Tunnels. J. Am. Chem. Soc. 2023. https://doi.org/10.1021/jacs.3c00195.
12. Wang, X.#; Lin, X.#; Jiang, Y.#; Qin, X.#; Ma, N.; Yao, F.; Dong, S.; Liu, C.; Feng, Y.; Jin, L.; Xian, M.; Cong, Z.* Engineering Cytochrome P450BM3 Enzymes for Direct Nitration of Unsaturated Hydrocarbons. Angew. Chem. Int. Ed Engl. 2023, e202217678.
11. Chen, J.#; Dong, S.#; Fang, W.#; Jiang, Y.; Chen, Z.; Qin, X.; Wang, C.; Zhou, H.; Jin, L.; Feng, Y.*; Wang, B.*; Cong, Z.* Regiodivergent and Enantioselective Hydroxylation of C-H Bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules. Angew. Chem. Int. Ed Engl. 2023, 62 (4), e202215088
10. Zhang, X.#; Jiang, Y.#; Chen, Q.#; Dong, S.; Feng, Y.*; Cong, Z.*; Shaik, S.; Wang, B.* H-Bonding Networks Dictate the Molecular Mechanism of H2O2 Activation by P450. ACS Catal. 2021, 11 (14), 8774–8785.
9. Ma, N.#; Fang, W.#; Liu, C.; Qin, X.; Wang, X.; Jin, L.; Wang, B.*; Cong, Z.* Switching an Artificial P450 Peroxygenase into Peroxidase via Mechanism-Guided Protein Engineering. ACS Catal. 2021, 11 (14), 8449–8455.
8. Zhao, P.#; Chen, J.#; Ma, N.; Chen, J.; Qin, X.; Liu, C.; Yao, F.; Yao, L.; Jin, L.; Cong, Z.* Enabling Highly (R)-Enantioselective Epoxidation of Styrene by Engineering Unique Non-Natural P450 Peroxygenases. Chem. Sci. 2021, 12 (18), 6307–6314.
7. Jiang, Y.#; Wang, C.#; Ma, N.; Chen, J.; Liu, C.; Wang, F.; Xu, J.*; Cong, Z.* Regioselective Aromatic O-Demethylation with an Artificial P450BM3 Peroxygenase System. Catal. Sci. Technol. 2020, 10 (5), 1219–1223.
6. Chen, J.; Kong, F.; Ma, N.; Zhao, P.; Liu, C.; Wang, X.; Cong, Z.* Peroxide-Driven Hydroxylation of Small Alkanes Catalyzed by an Artificial P450BM3 Peroxygenase System. ACS Catal. 2019, 9 (8), 7350–7355.
5. Ma, N.#; Chen, Z.#; Chen, J.#; Chen, J.; Wang, C.; Zhou, H.; Yao, L.; Shoji, O.; Watanabe, Y.; Cong, Z.* Dual-Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase. Angew. Chem. Int. Ed Engl. 2018, 57 (26), 7628–7633.
2011年-2015年
4. Cong, Z.; Shoji, O.*; Kasai, C.; Kawakami, N.; Sugimoto, H.; Shiro, Y.; Watanabe, Y.* Activation of Wild-Type Cytochrome P450BM3 by the next Generation of Decoy Molecules: Enhanced Hydroxylation of Gaseous Alkanes and Crystallographic Evidence. ACS Catal. 2015, 5 (1), 150–156.
3. Cong, Z.; Yanagisawa, S.; Kurahashi, T.; Ogura, T.; Nakashima, S.; Fujii, H.* Synthesis, Characterization, and Reactivity of Hypochloritoiron(III) Porphyrin Complexes. J. Am. Chem. Soc. 2012, 134 (51), 20617–20620.
2. Cong, Z.; Kurahashi, T.; Fujii, H.* Formation of Iron(III) Meso-Chloro-Isoporphyrin as a Reactive Chlorinating Agent from Oxoiron(IV) Porphyrin π-Cation Radical. J. Am. Chem. Soc. 2012, 134 (10), 4469–4472.
1. Cong, Z.; Kurahashi, T.; Fujii, H.* Oxidation of Chloride and Subsequent Chlorination of Organic Compounds by Oxoiron(IV) Porphyrin π-Cation Radicals. Angew. Chem. Int. Ed Engl. 2011, 50 (42), 9935–9939.